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Night Shift Rx Face Serum, our prescription strength retinoid formulated with Tretinoin and Niacinimide is the backbone of a nightly skincare routine. Proven to prevent and treat fine lines, wrinkles, pigmentation, uneven skin tone, enlarged pores and acne. Tretinoin continues to be the gold standard in skincare, so it’s no wonder this dermatologist-tested super serum is making gains. Get your tailored prescription without leaving your home.
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*At checkout, answer questions and upload photos of your skin for your provider to determine if a prescription is appropriate.

Tretinoin Face Prescription Online

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First-time bottle lasts ~2 months. Refills last ~3 months and bill at $99/quarter. Change frequency or cancel anytime.
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Enjoy the ease of an online dermatologist review and get your Tretinoin, a prescription strength retinoid online.
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Bonus ingredient: Niacinamide, an anti-inflammatory healing compound that calms redness and boosts hydration.
AGING IS LIVINGâ„¢

Anti-aging doesn't exist in our dictionary. We're pro-aging and here to do it better than ever. When you're comfortable in your skin, you're more confident in yourself. And when you're confident in yourself, you embrace that aging is living - a belief that shines from the skinside out. Get your tailored Tretinoin prescription online today.

GET TO KNOW NIGHT SHIFT

Night Shift is formulated with a powerful blend of Tretinoin, a prescription strength retinoid, and gentle, hydrating ingredients to transform your nightly skincare routine. Harnessing the dynamic duo of Tretinoin and Niacinamide, our tailored formula from skin experts is made for your unique skin. Our silky-smooth texture indulges your skin with every application.

TRETINOIN SERUM + NIACINAMIDE BENEFITS

Trust the science. Your Tretinoin prescription online is proven to prevent and treat wrinkles, pigmentation, uneven skin tone, enlarged pores, and acne. Its redness-reducing anti-inflammatory partner, niacinamide, reduces the appearance of big pores, prevents moisture loss and dehydration, and brightens the skin. Like every perfect match, they work together to reveal your best skin ever.

The power of retinoids.

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Retinoid stimulates the production of collagen, softening the appearance of fine lines and wrinkles. They also boost new blood vessels, which can give you a youthful rosy glow.
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Yes! Retinoids clear cellular debris around enlarged pores, making them appear smaller and keeping them cleaner.
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Retinoids are a first-line defense for treating and preventing blackheads as they decrease comedones and their precursor, thereby decreasing non inflammatory and inflammatory acne.
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Tough acne that hasn’t responded to your usual treatments may respond well to a topical tretinoin prescription online. Retinoids unclog pores, which means your skin will absorb creams more efficiently.
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Since topical retinoids exfoliate the skin, they definitely aid in the natural elimination of milia. It also iImproves roughness by reducing the layer of dead skin cells and increasing glycosaminoglycan (GAG).
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While not a cure-all for every type of hyperpigmentation, anti-inflammatory topical retinoids can improve pigmentation of freckles, melasma, sun spots and dark spots by dispersing melanin granules.
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Tretinoin

This topical retinoid helps the skin by removing dead layers of skin and unclogging pores. Depending on your skin profile evaluation, your online Tretinoin prescription strengths can range from 0.015% to .089%
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Niacinamide

Also called nicotinamide, this anti-aging NSAID is a form of B3 found in many common foods. It’s required for well functioning fats and sugars in the body and the maintenance of healthy cells.
Base: ST-Elastomer 10, Q7-9120 Silicone Fluid, EL-7040 Hydro Elastomer Blend, Vitamin E Acetate, Liquid, Polyglycerol-3 Diisostearique
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ALCHOHOL FREE
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CRUELTY FREE
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FRAGRANCE FREE
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PARABEN FREE

As easy as 1-2-3.

Get a tailored solution from our dermatologist partners to match your unique skin profile – gentle enough for even the most sensitive skin.
Sustainable

STEP 1

Share your skin goals
No need for an in-person visit to the
dermatologist. In just a few minutes, share details about your skin and upload photos on our secure telehealth portal.
Sustainable

STEP 2

Our doctors tailor your formula
You are unique and your skin is too. A doctor will review your profile and tailor your derm-strength Night Shift serum to create a formula just for you.
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STEP 3

Check in with your skin coach
Like any fitness routine, retinoids work best by starting out slowly. Your provider is available at any time to check in and assess your progress.

Night Shift for anyone and everyone.

Whether you have sensitive or dry skin, or whether you’re a retinoid rookie or not, our Board-certified doctors got you. Understanding that everyone's skin is different, they provide you with an appropriate strength of our tailored Tretinoin prescription for your specific skin type.

When your skin is ready, they’ll even upgrade your strength. At Dear Brightly we are committed to giving you a better overall retinoid experience.
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Start seeing results as early as 2 weeks.*

Practice makes progress! Start slowly, be patient, and watch your skin transform. Collagen isn’t built in a day, so we’ve made sure you’ve got the right routine for the journey. And we’re here to be your coach, teammate, and biggest fan – every step of the way.

*Individual results may vary
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1-2 weeks
Brightens and reduces uneven skin tone.
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2-4 weeks
Discoloration is improved.
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4-6 weeks
Brown spots diminish.
Person gently applying skincare product to their cheek with eyes closed.
3-6 months
Reduced fine lines and wrinkles.
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6 months - 1 year
Clear, radiant skin

Community Reviews

Perimenopause Skin Fix! Perimenopause hit my skin as if I was 15 again—- and working 3 weeks, my acne has calmed, my skin is softer, it feels so much healthier too. I also love the feeling of putting the cream on at night (I still use the sandwich method with DailySip). Thrilled with this product!
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Vanessa Ford
6/13/2024
Loving the Night Shift I have been using Night Shift for 3 months now. I can really tell a difference in my skin. It looks healthier and I have gotten lots of comments about how good my skin looks. I am not experiencing any peeling or redness from using it and I am able to use it every night. I would highly recommend giving Night Shift a try if you are looking to amp up your skincare routine.
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Andrea Williams
3/17/2024
I started using this... I started using this product amid a horrible breakout on my cheeks. It took about three months to notice a difference since my skin tends to be very sensitive and I had to dip my toes in the water beforehand. I'm now up to three days a week and my skin continues to show weekly improvement. I'm glad I took the chance.
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Hillary
3/15/2024

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